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Theoretical and Computational Biophysics
Changbong Hyeon works mostly on theoretical and computational studies of biological systems. The emergence of life from individual physicochemical processes of cellular constituents is a major outstanding question in biophysics. The research interests of this group lie in the dynamics of DNA, RNA, and proteins at the single molecule level, as well as in the interactions among these molecules in giant macromolecular complexes such as chromosomes. Studies towards understanding biological phenomena at the systems level are a long-term research goal. Major contributions have recently been made in areas such as: (i) the physical principles underlying molecular motors, (ii) the origin of heterogeneity in bimolecular processes, and (iii) nonequilibrium thermodynamics in living systems.

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AUTHOR | L. Liu, P. A. Pincus, C. Hyeon |
TITLE | Compressing ¥È-chain in slit geometry |
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JOURNAL | Nano Letters (2019) 19, 5667-5673 |
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AUTHOR | L. Liu, M. H. Kim, C. Hyeon |
TITLE | Heterogeneous loop model to infer 3D chromosome structures from Hi-C |
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JOURNAL | Biophys. J. (2019) 117, 613-625 |
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AUTHOR | D. Thirumalai, C. Hyeon, P. I. Zhuravlev, G. H. Lorimer |
TITLE | Symmetry, Rigidity, and Allosteric Signaling: From Monomeric Proteins to Molecular Machines |
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JOURNAL | Chemical Reviews (2019) 119, 6788-6821 |
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AUTHOR | L. Liu, G. Shi, D. Thirumalai, C. Hyeon |
TITLE | Chain organization of human interphase chromosome determines the spatiotemporal dynamics of chromatin loci |
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JOURNAL | PLOS Comp. Biol. (2018) 14, e1006175, 2018 |
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AUTHOR | W. Hwang, Y. Yoo, Y. Lee, S. Park, P. L. Hoang, H. Cho, J. Yu, T. M. H. Vo, M. Shin, M. S. Jin, D. Park, C. Hyeon, G. Lee |
TITLE | Dynamic Coordination of Two-Metal-Ions Orchestrates ¥ë-Exonuclease catalysis |
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JOURNAL | Nature Communications (2018) 9:4404 |
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NUMBER | |
AUTHOR | S. Lee, C. Hyeon, J. Jo |
TITLE | Thermodynamic uncertainty relation of interacting oscillator in synchrony |
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JOURNAL | Phys. Rev. E. (2018) 98, 032119 |
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NUMBER | |
AUTHOR | G. Shi, L. Liu, C. Hyeon, D. Thirumalai |
TITLE | Interphase human chromosome exhibits out of equilibrium glassy dynamics |
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JOURNAL | Nature Communications (2018) 9:3161 |
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NUMBER | |
AUTHOR | S. Hyun, Y. Lee, S. M. Jin, J. Cho, J. Park, C. Hyeon, K.-S. Kim, Y. Lee, J. Yu |
TITLE | Oligomer Formation Propensities of Dimeric Bundle Peptides Correlate with Cell Penetration Abilities |
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JOURNAL | ACS Central Science (2018) 4, 885-893 |
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AUTHOR | J. H. Bak, S. J. Jang, C. Hyeon |
TITLE | Implications for human odor sensing revealed from the statistics of odorant-receptor interactions |
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JOURNAL | PLoS Comp. Biol. (2018) 14, e1006175 |
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NUMBER | |
AUTHOR | L. Liu, C. Hyeon |
TITLE | From Octopus to Dendrite - Semiflexible Polyelectrolyte Brush Condensates in Trivalent Counterion Solution |
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JOURNAL | J. Chem. Phys. (2018) 149, 163302 |
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NUMBER | |
AUTHOR | H. J. Kim, J.-H. Park, J. Kim, J. J. Kim, S. Hong, J. Kim, J. H. Kim, H. R. Woo, C. Hyeon, P. O. Lim, H. G. Nam, D. Hwang |
TITLE | Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2018) 115, E4930-E4939 |
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NUMBER | |
AUTHOR | Thirumalai, D.; Hyeon, Changbong |
TITLE | Signalling networks and dynamics of allosteric transitions in bacterial chaperonin GroEL: implications for iterative annealing of misfolded proteins |
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JOURNAL | PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. v.373, no.1749, article no.20170182. 2018 |
ABSTRACT | Signal transmission at the molecular level in many biological complexes occurs through allosteric transitions. Allostery describes the responses of a complex to binding of ligands at sites that are spatially well separated from the binding region. We describe the structural perturbation method, based on phonon propagation in solids, which can be used to determine the signal-transmitting allostery wiring diagram (AWD) in large but finite-sized biological complexes. Application to the bacterial chaperonin GroEL-GroES complex shows that the AWD determined from structures also drives the allosteric transitions dynamically. From both a structural and dynamical perspective these transitions are largely determined by formation and rupture of salt-bridges. The molecular description of allostery in GroEL provides insights into its function, which is quantitatively described by the iterative annealing mechanism. Remarkably, in this complex molecular machine, a deep connection is established between the structures, reaction cycle during which GroEL undergoes a sequence of allosteric transitions, and function, in a self-consistent manner. This article is part of a discussion meeting issue Allostery and molecular machines. |
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Publication(career)
NUMBER | |
AUTHOR | W. Hwang, C. Hyeon |
TITLE | Energetic Costs, Precision, and Transport Efficiency of Molecular Motors |
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JOURNAL | J. Phys. Chem. Lett. (2018) 9, 513-520 |
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NUMBER | |
AUTHOR | S. Chakrabarti, C. Hyeon, X. Ye, G. H. Lorimer, D. Thirumalai |
TITLE | Molecular chaperones maximize the native state yield on biological times by driving substrates out of equilibrium |
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JOURNAL | Proc. Natl. Acad. Sci. U. S. A. (2017) 114, E10919-E10927 |
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NUMBER | |
AUTHOR | Y. Lee, D. Thirumalai, C. Hyeon |
TITLE | Ultrasensitivity of water exchange kinetics to the size of metal ion |
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JOURNAL | J. Am. Chem. Soc. (Communication) (2017) 139, 12334-12337 |
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NUMBER | |
AUTHOR | C. Hyeon, W. Hwang |
TITLE | Physical insight into the thermodynamic uncertainty relation using Brownian motion in tilted periodic potentials |
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JOURNAL | Phys. Rev. E. (2017) 96, 012156 |
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AUTHOR | B. J. N Reddy, S. Tripathy, M. Vershinin, M. Tanenbaum, J. Xu, M. Mattson-Hoss, K. Arabi, D. Chapman, T. Doolin, C. Hyeon, S. P. Gross |
TITLE | Heterogeneity in kinesin function |
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JOURNAL | Traffic (2017) 18, 658-671 |
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NUMBER | |
AUTHOR | C. Hyeon, D. Thirumalai |
TITLE | Ripping RNA by Force using Gaussian Network Models |
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JOURNAL | J. Phys. Chem. B (2017) vol. 121, 3515-3522 |
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NUMBER | |
AUTHOR | S. Jang, C. Hyeon |
TITLE | A Kinetic Model for the Activation of Mammalian Olfactory Receptor |
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JOURNAL | J. Phys. Chem. B (2017) 121, 1304-1311 |
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NUMBER | |
AUTHOR | L. Liu, P. A. Pincus, C. Hyeon |
TITLE | Heterogeneous morphology and dynamics of polyelectrolyte brush condensates in trivalent counterion solution |
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JOURNAL | Macromolecules (2017) 50, 1579-1588 |
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NUMBER | |
AUTHOR | S. Jang, C. Hyeon |
TITLE | Quantifying the Heat Disspation from a Molecular Motors Transport Properties in Nonequilibrium Steady State |
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JOURNAL | J. Phys. Chem. Lett. (2017) 121, 1304-1311 |
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NUMBER | |
AUTHOR | W. Hwang, I. -B. Lee, S. -C. Hong, C. Hyeon |
TITLE | Decoding Single Molecule Time Traces with Dynamic Disorde |
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JOURNAL | PLoS Comp. Biol. (2016) 12(12), e1005286 |
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NUMBER | |
AUTHOR | Y. Lee, P. A. Pincus, C. Hyeon |
TITLE | Effects of dimethyl sulfoxide on surface water near phospholipid bilayers |
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JOURNAL | Biophys. J. (2016) vol. 111, 2481-2491 |
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NUMBER | |
AUTHOR | C. Jeon, C. Hyeon, Y. Jung, B.-Y. Ha |
TITLE | How are molecular crowding and the spatial organization of a biopolymer interrelated |
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JOURNAL | Soft Matter (2016) vol. 12, 9786-9796 |
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NUMBER | |
AUTHOR | Y. Lee, S. Kim, S. Choi, C. Hyeon |
TITLE | Ultraslow water-mediated transmembrane interactions regulate the activation of A2A adenosine receptor |
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JOURNAL | Biophysical Journal (2016) vol. 111, 1180-1191 |
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Publication(career)
NUMBER | |
AUTHOR | Michael Hinczewski, Changbong Hyeon, D. Thirumalai |
TITLE | Directly measuring single molecule heterogeneity using force spectroscopy |
ARCHIVE | 1605.07294 |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2016) vol. 113, E3852-E3861 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | Lei Liu, Changbong Hyeon |
TITLE | Contact statistics highlight distinct organizing principles of RNA and proteins |
ARCHIVE | 1604.00472 |
FILE | |
JOURNAL | Biophys. J. (2016) vol. 110, 2320-2327 |
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Publication(career)
NUMBER | |
AUTHOR | H. Kang, Y.-G. Yoon, D. Thirumalai, C. Hyeon |
TITLE | Confinement-induced glassy dynamics in a model for chromosome organization |
ARCHIVE | 1506.01089 |
FILE | |
JOURNAL | Phys. Rev. Lett. (2015) vol. 115, 198102 |
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Publication(career)
NUMBER | |
AUTHOR | H. Kang, N. M. Toan, C. Hyeon, D. Thirumalai |
TITLE | Unexpected swelling of stiff DNA in a polydisperse crowded environment |
ARCHIVE | 1505.01623 |
FILE | |
JOURNAL | J. Am. Chem. Soc. (2015) vol. 137, 10970-10978 |
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NUMBER | |
AUTHOR | S. E. Kim, I. -B. Lee, C. Hyeon, S.-C. Hong |
TITLE | Deciphering kinetic information from single molecule FRET data that show slow transitions |
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JOURNAL | J. Phys. Chem. B. (2015) vol. 119, 6974–6978 |
ABSTRACT | Single-molecule FRET is one of the most powerful and widely used biophysical techniques in biological sciences. It, however, often suffers from limitations such as weak signal and limited measurement time intrinsic to single- molecule fluorescence measurements. Despite several amelio- rative measures taken to increase measurement time, it is nearly impossible to acquire meaningful kinetic information on a molecule if conformational transitions of the molecule are ultraslow such that transition times (⟨¥ó⟩orig) are comparable to or longer than measurement times (¥ät) limited by the finite lifetime of fluorescent dye. Here, to extract a reliable and accurate mean transition time from a series of short time traces with ultraslow kinetics, we suggest a scheme called sHaRPer (serialized Handshaking Repeated Permutation with end removal) that concatenates multiple time traces. Because data acquisition frequency f and measurement time (¥ät) affect the estimation of mean transition time (⟨¥ó⟩), we provide mathematical criteria that f, ¥ät, and ⟨¥ó⟩ should satisfy to make ⟨¥ó⟩ close enough to ⟨¥ó⟩orig. Although application of the sHaRPer method has a potential risk of distorting the time constants of individual kinetic phases if the data are described with kinetic partitioning, we also provide criteria to avoid such distortion. Our sHaRPer method is a useful way to handle single-molecule data with slow transition kinetics. This study provides a practical guide to use sHaRPer. |
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Publication(career)
NUMBER | |
AUTHOR | J.-K. Ryu, D. Min, S.-H. Rah, S. J. Kim, Y. Park, H. Kim, C. Hyeon, H. M. Kim, R. Jahn, T.-Y. Yoon |
TITLE | Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover |
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JOURNAL | Science (2015) vol. 347, 1485 |
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NUMBER | |
AUTHOR | J.-C. Lin, J. Yoon, C. Hyeon, D. Thirumalai |
TITLE | Using Simulations and kinetic network models to reveal the dynamics and functions of riboswitches |
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JOURNAL | Methods in Enzymology (2015) vol. 553, 235-258 |
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NUMBER | |
AUTHOR | H. Kang, P. A. Pincus, C. Hyeon, D. Thirumalai |
TITLE | Effects of macromolecular crowding on the collapse of biopolymers |
ARCHIVE | 1409.5663 |
FILE | |
JOURNAL | Phys. Rev. Lett. (2015) vol. 114, 068303 |
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NUMBER | |
AUTHOR | Y. Lee, S. Choi, C. Hyeon |
TITLE | Communication over the network of binary switches regulates the activation of A2A adenosine receptor |
ARCHIVE | 1411.5360 |
FILE | |
JOURNAL | PLoS Comp. Biol. (2015) 11(2): e1004044. |
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NUMBER | |
AUTHOR | W. Bae , K. Kim, D. Min, J.-K. Ryu, C. Hyeon, T.-Y. Yoon |
TITLE | Programmed folding of DNA origami structures through single-molecule force control |
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JOURNAL | Nat. Commun (2014) vol. 5, 5654 |
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NUMBER | |
AUTHOR | S. Kim, I.-B. Lee, C. Hyeon, S.-C. Hong |
TITLE | Destabilization of i-motif by submolar concentrations of a monovalent cation |
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FILE | |
JOURNAL | J. Phys. Chem. B. (2014) vol. 118, 4753-4760. |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon, M. Hinczewski, D. Thirumalai |
TITLE | Evidence of disorder in biological molecules from single molecule pulling experiments |
ARCHIVE | 1402.6683 |
FILE | |
JOURNAL | Phys. Rev. Lett.(2014) 112, 138101 |
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NUMBER | |
AUTHOR | C. Hyeon, N. A. Denesyuk, D. Thirumalai |
TITLE | Development and applications of Coarse Grained models for RNA |
ARCHIVE | 1402.6030 |
FILE | |
JOURNAL | Israel J. Chem. (2014) vol. 54, 1358-1373 |
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NUMBER | |
AUTHOR | J. Yoon, J.-C. Lin, C. Hyeon, D. Thirumalai |
TITLE | Dynamical Transition and Heterogeneous Hydration Dynamics in RNA |
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FILE | |
JOURNAL | J. Phys. Chem. B. (2014) vol. 118, 7910-7919 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | S. Kim, I.-B. Lee, C. Hyeon, S.-C. Hong |
TITLE | Destabilization of i-motif by submolar concentrations of a monovalent cation |
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FILE | |
JOURNAL | J. Phys. Chem. B. (2014) vol. 118, 4753-4760. |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon, M. Hinczewski, D. Thirumalai |
TITLE | Evidence of disorder in biological molecules from single molecule pulling experiments |
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FILE | |
JOURNAL | Phys. Rev. Lett. (2014) vol. 112, 138101 |
ABSTRACT | |
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NUMBER | |
AUTHOR | J.-C. Lin, C. Hyeon, D. Thirumalai |
TITLE | Sequence-dependent folding landscapes of adenine riboswitch aptamers |
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FILE | |
JOURNAL | Phys. Chem. Chem. Phys. (2014) vol. 16, 6376 |
ABSTRACT | |
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NUMBER | |
AUTHOR | Y. Lee, S. Choi, & C. Hyeon |
TITLE | Mapping the intramolecular signal transduction of G-protein coupled receptors |
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JOURNAL | Proteins: Struct. Func. Bioinfo. (2014) vol. 82, 727-743 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Generalized Iterative Annealing Model for the action of RNA chaperones |
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JOURNAL | J. Chem. Phys. (2013) vol. 139, 121924 |
ABSTRACT | |
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NUMBER | |
AUTHOR | J. Yoon, D. Thirumalai, C. Hyeon |
TITLE | Urea-induced denaturation of preQ1-riboswitch |
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FILE | |
JOURNAL | J. Am. Chem. Soc. (2013) vol. 135, 12112 |
ABSTRACT | |
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NUMBER | |
AUTHOR | W. Bae, M.-G. Choi, C. Hyeon, Y.-K. Shin, T.-Y. Yoon |
TITLE | Real-Time Observation of Multiple Protein-Complex Formation with Single-Molecule FRET |
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JOURNAL | J. Am. Chem. Soc. (2013) vol. 135, 10254 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | D. Min, K. Kim, C. Hyeon, Y. H. Cho, Y.-K. Shin, T.-Y. Yoon |
TITLE | Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism |
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JOURNAL | Nat. Commun. (2013) vol. 4, 1705 |
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NUMBER | |
AUTHOR | H.-W. Lee, T. Kyung, J. Yoo, T. Kim, C. Chung, J.Y. Ryu, H. Lee, K. Park, S. Lee, W.D. Jones, D.-S. Lim, C. Hyeon, W.D. Heo, T.-Y. Yoon |
TITLE | Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signaling dynamics |
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JOURNAL | Nat. Commun. (2013) vol. 4, 1505 |
ABSTRACT | |
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NUMBER | |
AUTHOR | J.-C. Lin, C. Hyeon, D. Thirumalai |
TITLE | RNA under Tension: Folding Landscapes, Kinetic Partitioning Mechanism, and Molecular Tensegrity |
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JOURNAL | J. Phys. Chem. Lett. (2012) vol. 3, 3616 |
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NUMBER | |
AUTHOR | B. Jana, C. Hyeon, J. N. Onuchic |
TITLE | The origin of minus-end directionality and mechanochemistry of Ncd motors |
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JOURNAL | PLoS Comp. Biol. (2012) vol. 8, e1002783 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon, J. Lee, J. Yoon, S. Hohng, D. Thirumalai |
TITLE | Hidden Complexity in the Isomerization Dynamics of Holliday Junctions |
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JOURNAL | Nature Chem. (2012) vol.4, 907 |
ABSTRACT | |
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NUMBER | |
AUTHOR | W. K. Kim, C. Hyeon, W. Sung |
TITLE | Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension |
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JOURNAL | Proc. Natl. Acad. Sci. (2012) vol. 109, 14410 |
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NUMBER | |
AUTHOR | C. Hyeon and. D. Thirumalai |
TITLE | Multiple barriers in forced rupture of protein complexes |
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FILE | |
JOURNAL | J. Chem. Phys. (2012) vol. 137, 055103 |
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NUMBER | |
AUTHOR | H.-K. Na, M.-H. Kim, K. Park, S.-R. Ryoo, K.E. Lee, H. Jeon, R. Ryoo, C. Hyeon, D.-H. Min |
TITLE | Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores |
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JOURNAL | Small (2012) vol. 8, 1752 |
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NUMBER | |
AUTHOR | C. Hyeon |
TITLE | Force-induced Unbinding Dynamics in a Multidimensional Free Energy Landscape |
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JOURNAL | Bull. Korean Chem. Soc. (2012) vol. 33, 897 |
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NUMBER | |
AUTHOR | C. Hyeon, D. Thirumalai |
TITLE | Chain Length Determines the Folding Rates of RNA |
ARCHIVE | |
FILE | |
JOURNAL | Biophys. J. (2012) 102, L11-L13 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C.Hyeon, J. N. Onuchic |
TITLE | A structural perspective on the dynamics of kinesin motors |
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FILE | |
JOURNAL | Biophys. J. (2011) vol. 101, 2749 |
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NUMBER | |
AUTHOR | Y. Lee, LS Jeong, S. Choi, C. Hyeon |
TITLE | Link between Allosteric Signal Transduction and Functional Dynamics in a Multisubunit Enzyme: S-Adenosylhomocysteine Hydrolase |
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JOURNAL | J. Am. Chem. Soc. (2011) 113, 19807-19815 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Capturing the essence of folding and functions of biomolecules using Coarse-Grained models |
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FILE | |
JOURNAL | Nature Communication (2011) vol. 2, 487 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | Greg Morrison, Changbong Hyeon, Michael Hinczewski |
TITLE | Compaction and Tensile Forces Determine the Accuracy of Folding Landscape Parameters from Single Molecule Pulling Experiments |
ARCHIVE | |
FILE | prl2011.pdf |
JOURNAL | Phys. Rev. Lett. (2011) 106, 138102 |
ABSTRACT | We establish a framework for assessing whether the transition state location of a biopolymer, which can be inferred from single molecule pulling experiments, corresponds to the ensemble of structures that have equal probability of reaching either the folded or unfolded states (Pfold=0.5). Using results for the forced unfolding of a RNA hairpin, an exactly soluble model, and an analytic theory, we show that Pfold is solely determined by s, an experimentally measurable molecular tensegrity parameter, which is a ratio of the tensile force and a compaction force that stabilizes the folded state. Applications to folding landscapes of DNA hairpins and a leucine zipper with two barriers provide a structural interpretation of single molecule experimental data. Our theory can be used to assess whether molecular extension is a good reaction coordinate using measured free energy profiles. |
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Publication(career)
NUMBER | |
AUTHOR | D. Thirumalai, EP Obrien, G. Morrison, C. Hyeon |
TITLE | Theoretical Perspectives on Protein Folding |
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JOURNAL | Annu. Rev. Biophys. (2010) vol. 39, 159-183 |
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NUMBER | |
AUTHOR | H. -K. Lee, Y. Yang, Z. Su, C. Hyeon, T. -S. Lee, H. -W. Lee, D. -H. Kwon, Y. -K. Shin and T. -Y. Yoon |
TITLE | Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1 |
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JOURNAL | Science (2010) vol. 328, 760-763 |
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NUMBER | |
AUTHOR | U. D. Priyakumar, C. Hyeon, D. Thirumalai and A. D. MacKerell Jr. |
TITLE | Urea destabilizes RNA by forming stacking interaction and multiple hydrogen bonds with nucleic acid bases |
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JOURNAL | J. Am. Chem. Soc. (2009) Vol. 131, 17759-17761 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon, G. Morrison, D. L. Pincus and D. Thirumalai |
TITLE | Refolding dynamics of stretched biopolymers upon force-quench |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2009) Vol. 106, 20288-20293 |
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NUMBER | |
AUTHOR | S. Moghaddam, G. Caliskan, S. Chauhan, C. Hyeon, R. M. Briber, D. Thirumalai and S. A. Woodson |
TITLE | Metal Ion Dependence of Cooperative Collapse Transitions in RNA |
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JOURNAL | J. Mol. Biol. (2009) Vol. 393, 753-764 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon, S. Klumpp and J. N. Onuchic |
TITLE | Kinesins Backsteps under Mechanical Load |
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JOURNAL | Phys. Chem. Chem. Phys. (2009) vol. 11, 4899-4910 |
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NUMBER | |
AUTHOR | C. Hyeon, P. A. Jennings, J. A. Adams and J. N. Onuchic |
TITLE | Ligand-induced global transition in the catalytic domain of protein kinase A |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2009) vol. 106, 3023-3028 |
ABSTRACT | |
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NUMBER | |
AUTHOR | C. Hyeon, G. Morrison and D. Thirumalai |
TITLE | Force dependent hopping rates of RNA hairpins can be estimated from accurate measurement of the folding landscapes |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2008) vol. 105, 9604-9609 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | D. L. Pincus, C. Hyeon and D. Thirumalai |
TITLE | Effects of Trimethylamine N-Oxide (TMAO) and Crowding Agents on the stability of RNA hairpins |
ARCHIVE | |
FILE | |
JOURNAL | J. Am. Chem. Soc. (2008) vol. 130. 7364-7372 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | N. M. Toan, G. Morrison, C. Hyeon and D. Thirumalai |
TITLE | Kinetics of loop formation in polymer chains |
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FILE | |
JOURNAL | J. Phys. Chem. B (2008) vol. 112 6094-6106 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Multiple probes are required to explore and control the rugged energy landscape of RNA hairpins |
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FILE | |
JOURNAL | J. Am. Chem. Soc. (2008) vol. 130 1538-1539 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | M. Michkler, R. I. Dima, H. Dietz, C. Hyeon, D. Thirumalai and M. Rief |
TITLE | Revealing the bifurcation in the unfolding pathways of GFP using single molecule experiments and simulations |
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FILE | |
JOURNAL | Proc. Natl. Acad. Sci. USA (2007) vol. 104 20268-20273 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and J. N. Onuchic, |
TITLE | Mechanical control of the directional stepping dynamics of the kinesin motor |
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FILE | |
JOURNAL | Proc. Natl. Acad. Sci. (2007) vol. 104 17382-17387 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | G. Morrison, C. Hyeon, N. M. Toan, B. -Y. Ha and D. Thirumalai |
TITLE | Stretching Homopolymers |
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FILE | |
JOURNAL | Macromolecules (2007) vol. 40 7343-7353 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | E. Koculi, C. Hyeon, D. Thirumalai, and S. A. Woodson, J. Am. Chem |
TITLE | Charge density of divalent metal cations determines RNA stability |
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FILE | |
JOURNAL | Soc. (2007) vol. 129 2676-2682 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and J. N. Onuchic |
TITLE | Internal strain regulates the nucleotide binding site of the kinesin leading head |
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FILE | |
JOURNAL | Proc. Natl. Acad. Sci. USA (2007) vol. 104 2175-2180 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Mechanical unfolding of RNA: From hairpins to structures with internal multiloops |
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FILE | |
JOURNAL | Biophys. J. (2007) vol. 92 731-743 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon, G.H. Lorimer and D. Thirumalai |
TITLE | Dynamics of allosteric transitions in GroEL |
ARCHIVE | |
FILE | |
JOURNAL | Proc. Natl. Acad. Sci. USA (2006) vol. 103 18939-18944 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon, R. I. Dima, and D. Thirumalai, J. Chem |
TITLE | Size, Shape, and flexibility of RNA structures |
ARCHIVE | |
FILE | |
JOURNAL | Phys. (2006) vol. 125 194905 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon, R.I. Dima, and D. Thirumalai |
TITLE | Pathways and kinetic barriers in mechanical unfolding and refolding of RNA and proteins |
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FILE | |
JOURNAL | Structure (2006) vol. 14 1633-1645 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Forced-Unfolding and Force-Quench Refolding of RNA Hairpins |
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FILE | |
JOURNAL | Biophys. J. (2006) vol. 90 3410-3427 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai, |
TITLE | Kinetics of interior loop formation in semiflexible chains |
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FILE | |
JOURNAL | J. Chem. Phys. (2006) vol. 124 104905 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | G. Caliskan, C. Hyeon, U. Perez-Salas, B.M. Briber, S.A. Woodson, and D. Thirumalai |
TITLE | Persistence Length Changes Dramatically as RNA Folds |
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FILE | |
JOURNAL | Phys. Rev. Lett. (2005) vol. 95 268303 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | R.I. Dima, C. Hyeon, and D. Thirumalai |
TITLE | Extracting Stacking Interaction Parameters for RNA from the Data Set of Native Structures |
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JOURNAL | J. Mol. Biol. (2005) vol. 347 53-69 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Mechanical unfolding of RNA hairpins |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2005) vol. 102 6789-6794 |
ABSTRACT | |
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Publication(career)
NUMBER | |
AUTHOR | C. Hyeon and D. Thirumalai |
TITLE | Can energy landscape roughness of proteins and RNA be measured using mechanical unfolding experiments? |
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JOURNAL | Proc. Natl. Acad. Sci. USA (2003) vol. 100 10249-10253 |
ABSTRACT | |
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NUMBER | |
AUTHOR | M. Paik Suh, M.Y. Han, J.H.Lee K.S.Min, and C. Hyeon. |
TITLE | One-pot Template Synthesis and Properties of a Molecular Bowl: Dodecaaza Macrotetracycle with mu(3)-Oxo and mu(3)-Hydroxo Tricopper(II) Cores |
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JOURNAL | J. Am. Chem. Soc. (1998) vol. 120, 3819-3820 |
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NUMBER | |
AUTHOR | Y. Jung, C. Hyeon, S. Shin, and S. Lee, J. Chem |
TITLE | Effects of a quantum-mechanically driven two-state gating mode on the diffusion-influenced bimolecular reactions |
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JOURNAL | Phys. (1997) vol. 107 9864 |
ABSTRACT | |

- 2010-present Professor of Computational Sciences, Korea Institute for Advanced Study, Seoul
- 2008-2009 Assistant Professor, Chemistry, Chung-Ang University, Seoul
- 2006-2008 Postdoctoral Research Associate, Center for Theoretical Biological Physics, UC San Diego
- 2000-2005 Ph.D., Chemical Physics, University of Maryland, College Park
- 1995-1997, M.S., Chemistry, Seoul National University
- 1991-1995, B.S., Chemistry, Seoul National University
- Office:7302 / TEL) 82-2-958-3810 / FAX) 82-2-958-3820
- School of School of Computational Sciences, Korea Institute for Advanced Study
85 Hoegiro, Dongdaemun-gu, Seoul 02455, Korea